Comprehensive genetic analysis by targeted sequencing identifies risk factors and predicts patient outcome in Mantle Cell Lymphoma: results from the EU-MCL network trials

Type: Scientific Paper
Published: September 16, 2024

The authors demonstrate that applying the EuroClonality-NDC assay to DNA samples from peripheral blood and bone marrow reliably detects diagnostically and prognostically important genetic factors in MCL patients, facilitating genetic characterization in clinical routine.

Mutational and transcriptional landscape of pediatric B-cell precursor lymphoblastic lymphoma

Type: Scientific Paper
Published: July 4, 2024

Describes the molecular relationship between BCP-ALL and BCP-LBL using whole exome sequencing / transcriptomics. EuroClonality-NDC was used for IG/TR rearrangement analysis.

Large cell lymphoma through a liquid lens

Type: Commentary/Editorial
Published: May 30, 2024

Commentary/Editorial on the liquid biopsy manuscript below.

Liquid biopsy for molecular characterization of diffuse large B-cell lymphoma and early assessment of minimal residual disease

Type: Scientific Paper
Published: May 29, 2024

Describes the application of EuroClonality-NDC for cfDNA analysis in DLBCL during treatment and its association with clinical outcomes.

Development of a fully automated workflow for integrated genomic profiling of haematological malignancies

Type: Conference Poster
Published: April 10, 2024

Shows the robustness of a fully automated protocol for the analysis of EuroClonality-NDC and Myeloid-NDC assays.

A novel next-generation sequencing capture-based strategy to report somatic hypermutation status using genomic regions downstream to immunoglobulin rearrangements

Type: Scientific Paper
Published: November 23, 2023

Describes a novel method to detect somatic hypermutation in IGH using the EuroClonality-NDC assay.

Genetic drivers in the natural history of chronic lymphocytic leukemia development as early as 16 years before diagnosis

Type: Scientific Paper
Published: October 19, 2023

Describes the natural history of CLL using multiple technologies, including the EuroClonality-NDC assay.

Genotyping and Minimal Residual Disease (MRD) Assessment in cfDNA By the Euroclonality-NGS DNA Capture (EC-NDC) Panel in Mantle Cell Lymphoma (MCL)

Type: Conference Abstract
Published: November 15, 2022

Application of EuroClonality-NDC for cfDNA genotyping and MRD analysis in MCL.

Immunoglobulin/T Cell Receptor Capture Strategy for Comprehensive Immunogenetics

Type: Scientific Paper
Published: May 28, 2022

A more technical description of the EuroClonality-NGS DNA Capture (EuroClonality-NDC) assay, with step-by-step instructions and tips.

Validation of the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders

Type: Scientific Paper
Published: August 20, 2021

This is the main manuscript by the EuroClonality-NGS Working Group describing the validation and performance of the EuroClonality-NDC.